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Buy Flibanserin (addyi) Pills Online
The article below provides a descriptive summary of Flibanserin, shares an overview of its application and analyses diversified side effects, as well as includes useful information for every patient who plans to use it.
What is addyi?
Flibanserin represents a modulator of 5-HT receptor, which is applied to treat specific premenopausal female patients, who have generalized, acquired, hypoactive sexual desire disorder (HSDD).
Flibanserin is among the first medications that have received FDA approval for treatment of premenopausal women from hypoactive sexual desire disorder (HSDD) back in August 2015. Initially, this medication was acting like an antidepressant, however with time it didn’t result in sufficient efficacy during various trials and was subsequently modified to become a hypoactive sexual disorder treatment. The mechanism of Flibanserin action is related to its close affinity with 5-HTA1 and 5-HTA2 receptors, exhibiting agonist action on 5-HTA1 and antagonist on 5-HTA2, which cause reduction of serotonin levels in the brain, while increasing dopamine and norepinephrine neurotransmitters amount.
Mechanism of Flibanserin Action
Flibanserin binds brain 5-HT1A and 5-HT2A receptors like serotonin. Libanserin may occupy 5-HT2A receptors more so than 5-HT(1A) receptors while under stress. Flibanserin may also antagonize D4 (dopamine) and 5-HT2B/C receptors. Neurotransmitter receptors diminish serotonin and enhance norepinephrine and dopamine. This might lead to a good outcome of therapy.
Addyi Side Effects
Flibanserin may result in the following side effects:
- CNS depression
- Sedation
- Somnolence
- Insomnia
- Fatigue
- Dryness of mouth
Flibanserin patients should not drive or do other tasks that need full awareness for at least 6 hours after taking it. Avoid taking opioids, diphenhydramine, benzodiazepines, and hypnotics with Flibanserin. Syncope and hypotension may arise with flibanserin alone.
Various studies on mice have confirmed dose-associated increase in cases of malignant mammary tumors among female mice (exposure levels 3 and 10 times higher than the suggested clinical dose). This effect was not observed among male mice or in male/female rats.
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